Realizing Clinical Trials with Astatine-211: The Chemistry Infrastructure

CLINICAL TRIALS AND OBSERVATIONS Durable donor engraftment after radioimmunotherapy using -emitter astatine-211–labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation

To reduce toxicity associated with external -beam radiation, we investigated radioimmunotherapy with an anti-CD45 mAb labeled with the -emitter, astatine-211 (211At), as a conditioning regimen in dog leukocyte antigen-identical hematopoietic cell transplantation (HCT). Dose-finding studies in 6 dogs treated with 100 to 618 Ci/kg 211Atlabeled anti-CD45 mAb (0.5 mg/kg) without HCT rescue demonstr...

Developing a Clinical Trials Infrastructure in the United States

Evaluation of Clinical Trials

In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...

Evidence Based Medicine: Clinical Trials

Evidence based medicine is very important for success of modern medicine. It is the ongoing process of using the most reliable evidence from clinical studies, scientific understanding and medical practice to make the best possible medical choice for patients. Evidence based medicine is how medicine advances and how we get improvements in life expectancy and quality of life. It not only identifi...

Update on Cyclotron Production Studies of No-carrier- Added: Copper-64, Astatine-211/polonium-211g, Rhenium-186g

Selected results are presented and discussed concerning nuclear data relevant to the production of innovative medical radionuclides (RNs) of special interest, measurements of excitation functions of the involved nuclear reactions, in comparison with the corresponding theoretical calculations. Moreover, at the Radiochemistry Laboratory of Accelerators and Applied Superconductivity Laboratory, LA...